Computational Methodology For Protein Interaction Analysis

X-ray crystallography and nuclear magnetic resonance are two of the techniques recommended and used to characterize protein structures and complexes in studies. However, a significant portion of the proteins cannot be analyzed by such methods. Currently, there is a limitation of methodologies that allow the analysis of protein-protein interaction on a large scale. Mapping the epitope interaction region, i.e., the area of the antigen molecule that binds to cell receptors and antibodies, is a challenging task, and drug development depends on this mapping.

The technology proposes a method that, when applied to protein mixtures and subsequent analysis by the mass spectrometry technique, allows the characterization of protein complexes, epitope mapping, and protein-protein interaction on a large scale. Interaction identifications are performed using software developed by our team. In this way, the solution functions as an alternative to conventional methods of structural biology analysis.

Commercialization of the methodologies together with the software.